PLA.sub.2 inhibitors and their use for inhibition of intestinal cholesterol absorption
AssigneeWarner-Lambert Company
InventorReynold Homan
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Abstract
Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A.sub.2 (PLA.sub.2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.
Claims3
A method of treating atherosclerosis or coronary artery disease in a mammal suffering therefrom which comprises administering to said mammal a compound of the formula ##STR18## wherein R is hydrogen, hydroxy, lower alkyl, halogen, trifluoromethyl, cyano, nitro, methylthio, lower alkenyl, or lower alkynyl, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.