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AssigneeFidia S.p.A.
InventorsAlberto Perbellini, Gino Toffano, Aurelio Romeo
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The present invention relates to a new spongy material consisting essentially of hyaluronic acid or its derivatives. The characteristics of the new pharmaceutical preparations consist in assuring high concentrations of active principle for a long period of time, by exploiting the characteristics of slow release of the active principle. The new pharmaceutical preparations can be utilized advantageously in all the numerous situations of microsurgical practice (in particular the ones relating to ear or in odontostomatology), in which it is necessary to use a substance that can be metabolized by the organism and is capable of making easier flap take, reepithelialization of mucous membranes, stabilization of grafts and filling of cavities. The specific use of the new pharmaceutical preparations is particularly important and useful in the various ear pathologies and in the practice of otologic, otoneurosurgical and odontostomatological microsurgery, such as for instance repair of tympanic perforations.
A sterile slow release spongy material in a dose for a single topical application consisting essentially of a lyophilized non-crosslinked hyaluronic acid ester, said spongy material having an apparent volume ranging between 0.04 and 27 ml, an apparent density ranging between 0.00037 and 0.25 g/ml, an actual volume ranging between 0.01 and 2.5 ml, and an actual density ranging between 0.004 to 10 g/ml.
A method for treating wounds, which comprises applying to said wounds a sterile spongy material in a dose for a single topical application consisting essentially of lyophilized non-crosslinked hyaluronic acid or a derivative thereof.
A method of repairing tympanic wounds, which comprises applying to said tympanic wounds a sterile spongy material in a dose for a single topical application consisting essentially of non-crosslinked hyaluronic acid or a derivative thereof.
Dependencies are inferred from the claim text.