Substituted guanidines having high binding to the sigma receptor and the use thereof
AssigneeState of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon
InventorsJohn Keana, Eckard Weber
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Abstract
N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-disubstituted guanidine which, preferably, has a high affinity for the sigma receptor.
Claims6
A compound selected from the group consisting of N-(2-methyl-4-azidophenyl)-N'-(2-methylphenyl)guanidine, N,N'-di(o-methylbenzyl)guanidine, N,N-di(o-methylbenzyl)guanidine and N,N'-dibenzylguanidine.
A compound selected from the group consisting of tritium labeled N-(2-methyl-4-azidophenyl)-N'-(2-methylphenyl)guanidine, tritium labeled N,N'-di(o-methylbenzyl)guanidine, tritium labeled N,N-di(o-methylbenzyl)guanidine and N,N'-dibenzylguanidine.
Dependencies are inferred from the claim text.