.alpha.-aryl or heteroaryl-substituted amide ester ACAT inhibitors

A compound having the formula

• wherein Ar is
• (a) phenyl substituted with from 2 to 3 substituents selected from phenyl,
• alkyl having from 1 to 6 carbon atoms and which is straight or branched,
• alkoxy having from 1 to 6 carbon atoms and which is straight or branched,
• phenoxy,
• hydroxy,
• fluorine,
• chlorine,
• bromine,
• nitro,
• trifluoromethyl,
• --COOH,
• --COOalkyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, or
• --(CH.sub.2).sub.y NR.sub.17 R.sub.18 wherein y is 0 or 1 and each of R.sub.17 and R.sub.18 is independently selected from hydrogen or an alkyl group having from 1 to 4 carbon atoms;
• (b) 1- or 2-naphthyl which is substituted with from 2 to 3 substituents selected from
• phenyl,
• alkyl having from 1 to 6 carbon atoms and which is straight or branched,
• alkoxy having from 1 to 6 carbon atoms and which is straight or branched,
• hydroxy,
• fluorine,
• chlorine,
• bromine,
• nitro,
• trifluoromethyl,
• --COOH,
• --COOalkyl wherein alkyl has from 1 to 4 carbon atoms and which is straight or branched,
• --(CH.sub.2 ).sub.y NR.sub.17 R.sub.18 wherein y, R.sub.17, and R.sub.18 have the meanings defined above;
• or;
• (c) ##STR24## wherein R.sub.11, R.sub.12, and R.sub.13 are each independently (a) hydrogen,
• (b) alkyl of from 1 to 4 carbon atoms and which is straight or branched;
• (c) alkoxy of from 1 to 3 carbon atoms and which is straight or branched;
• (d) alkylthio of from 1 to 3 carbon atoms and which is straight or branched;
• (e) fluorine;
• (f) chlorine;
• (g) bromine;
• wherein R.sub.15 is a 5- or 6-membered monocyclic or fused bicyclic heterocycle containing at least 1 to 4 nitrogen, oxygen, or sulfur atoms in at least 1 ring member;
• wherein R.sub.16 is
• (a) a straight or branched hydrocarbon chain having from 10 to 20 carbon atoms and which is saturated or contains from 1 to 3 double bonds;
• N-oxides thereof, or a pharmaceutically acceptable salt thereof.