Contrast media synthesized from polyaldehydes
AssigneeSchering Corporation
InventorsGeorg Ro/ ssling, Celal Albayrak, Matthias Rothe, Joachim Siegert
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Abstract
Microparticles comprising biodegradable polymers, characterized in that they are synthesized from polymerizable aldehydes, which optionally contain additives and/or crosslinkers capable of copolymerization, optionally surfactants or surfactant mixtures, gases and/or highly volatile liquids in free or bound form, coupling agents, optionally biomolecules or macromolecules bound by these coupling agents as well as optionally diagnostically or therapeutically effective components, are suitable as ultrasonic contrast media.
Claims25
Microparticles consisting essentially of (a) a biodegradable polymer having a molecular weight of 1-30 Kd, obtainable by polymerizing a polymerizable aldehyde, and (b) 0.01-2 wt % of a gas and/or liquid with a boiling point below 60.degree. C. relative to the amount of polymer, said microparticles having a diameter of 0.1 to 40 .mu.m and said aldehyde having been polymerized in the presence of said gas and/or liquid.
Dependencies are inferred from the claim text.