Cysteine protease and serine protease inhibitors

A compound represented by the formula:

• ##STR42## wherein:
• M is selected from the group consisting of O, NR.sup.7 and CR.sup.1 R.sup.2 ;
• X.sup.1 is selected from the group consisting of O, S and NR.sup.7 ;
• X.sup.2 is selected from the group consisting of O, S, NR.sup.7 and two hydrogen atoms;
• Q is selected from the group consisting of O, S and NR.sup.1 ;
• R.sup.1 and R.sup.2 are each independently selected from the group consisting of H, alkyl having from 1 to 10 carbons, heteroaryl having from 1 to 10 carbons, alkanoyl having from 1 to 10 carbons, and aroyl, wherein said alkyl, heteroaryl, alkanoyl and aroyl groups are optionally substituted with J;
• R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently selected from the group consisting of H, alkyl having from 1 to 10 carbons, aryl, and heteroaryl, wherein said alkyl, aryl and heteroaryl groups are optionally substituted with J;
• R.sup.7 and R.sup.8 are each independently selected from the group consisting of H, alkyl having from 1 to 10 carbons, aryl, and heteroaryl, wherein said alkyl, aryl and heteroaryl groups are optionally substituted with J;
• J is selected from the group consisting of halogen, COOR.sup.7, R.sup.7 OCO, R.sup.7 OCONH, OH, CN, NO.sub.2, NR.sup.7 R.sup.8, N.dbd.C(R.sup.7)R.sup.8, N.dbd.C(NR.sup.7 R.sup.8).sub.2, SR.sup.7, OR.sup.7, phenyl, naphthyl, heteroaryl, and a cycloalkyl group having from 3 to 8 carbons;
• G is selected from the group consisting of NH.sub.2, NHR.sup.1, CH.sub.2 R.sup.1, CH.sub.2 C(O)B, carbobenzyloxy-NH, succinyl-NH, R.sup.7 O-succinyl-NH, R.sup.7 OC(O)NH, CH.sub.2 C(O)-(xanthen-9-yl), CH.sub.2 COR.sup.9 wherein R.sup.9 is selected from the group consisting of alkyl, aryl, and arylalkyl group of up to 13 carbons, and AA.sup.1 NHC(O)OCH.sub.2 C.sub.6 H.sub.5 wherein AA.sup.1 is selected from the group consisting of one of the 20 natural amino acids and an opposite antipode of said amino acid;
• B is selected from the group consisting of alkyl having from 1 to 10 carbons, aralkyl having from 1 to 10 carbons, aryl having 1 to 3 carbocyclic rings, and heteroaryl having 1 to 3 rings, wherein said alkyl, aralkyl, aryl and heteroaryl groups are optionally substituted with J;
• and
• A is represented by the structure:
• ##STR43## wherein:
• Y is selected from the group consisting of N and CR.sup.1 ;
• W is selected from the group consisting of a double bond and a single bond;
• D is a single bond;
• E and F are each independently selected from the group consisting of R.sup.1, R.sup.2, J, and when E and F comprise a joined moiety, said moiety is selected from the group consisting of an aliphatic carbocyclic ring having from 5 to 7 carbons, an aromatic carbocyclic ring having from 5 to 7 carbons, an aliphatic heterocyclic ring having from 5 to 7 atoms, and an aromatic heterocyclic ring having from 5 to 7 atoms;
• wherein:
• said aliphatic heterocyclic ring and said aromatic heterocyclic ring each have from 1 to 4 heteroatoms;
• and said
• aliphatic carbocyclic ring, said aromatic carbocyclic ring,
• said aliphatic heterocyclic ring, and said aromatic heterocyclic ring are each optionally substituted with J.