Tryptamine analogs with 5-HT1D selectivity

Abstract

Described herein are tryptamine analogs that display high binding affinity and selectivity for the 5-HT1D.beta. receptor, of the formula: ##STR1## wherein R.sup.1 represents a chain selected from C.sub.8-11 alkyl, C.sub.7-10 alkoxy, C.sub.8-11 alkanoyl and C.sub.7-10 alkanoyloxy wherein said chain is optionally substituted by hydroxyl, C.sub.1-4 alkyl or C.sub.1-4 alkoxy and wherein one of the intervening carbons of said chain is optionally replaced with a heteroatom selected from oxygen, nitrogen and sulfur; R.sup.2 and R.sup.3 each independently represent H or C.sub.1-3 alkyl; and R.sup.4 represents H, C.sub.1-4 alkyl, aryl or arylC.sub.1-4 alkyl; The compounds are useful as reagents for receptor identification and in receptor-based drug screening programs, and can also be used therapeutically to treat conditions for which administration of a 5-HT1D ligand is indicated, for example in the treatment of migraine.

Dependencies are inferred from the claim text.