Preparation of D-histidine and derivatives thereof from L-histidine
AssigneeBromine Compounds Ltd.
InventorsYigal Becker, Yonit Assaf-Biran, Youval Shvo
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Abstract
D-histidine and its derivatives are manufactured from L-histidine, by mixing L-histidine and tartaric acid with an aldehyde in acetic acid medium and thereafter precipitating D-histidine tartrate from the reaction mass. Pure D-histidine can then be recovered from the crude D-histidine tartrate.
Claims15
A process for manufacture of D-histidine or esters thereof from L-histidine, comprising the steps of mixing L-histidine and tartaric acid with an aldehyde selected from the group consisting of salicylaldehyde and 3,5-dichlorosalicylaldehyde in an acetic acid medium and thereafter precipitating D-histidine tartrate from the reaction mass.
Dependencies are inferred from the claim text.