Process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine
AssigneeSolar Chemical Corporation
InventorsTiberio Bruzzese, Giuseppe Guazzi, Marco Rognoni, Giuliano Marcon
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Abstract
A process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine in which guanine, or its salts, is reacted with 2-4 moles of hexamethyldisilazane, in the presence of an aprotic solvent and of ammonium sulfate. Thereafter, the trimethylsilyl derivative, without being isolated, is reacted with a stoichiometric quantity of an acyloxyethoxy methyl halide and hydrolyzed with aqueous sodium acetate or sodium hydroxyde to give 9-(2-hydroxyethyoxy methyl) guanine.
Claims10
A process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine, comprising reacting guanine, or a salt thereof with between 2 and 4 moles of hexamethyldisilazane, in the presence of an aprotic solvent and of a catalytic amount of ammonium sulphate;
- reacting the resulting guanine trimethylsilyl derivative, without being isolated, with a stoichiometric quantity of acyloxyethoxy methyl halide at a temperature of 50.degree. to 100.degree. C.;
- and hydrolyzing with a sodium acetate or sodium hydroxyde water solution the resulting 9-(2-acetoxyethoxy methyl) guanine, to provide 9-(2-hydroxyethoxy methyl) guanine.
Dependencies are inferred from the claim text.