Insecticide and miticide A83543 compounds and their method of production by fermentation
AssigneeDowElanco
InventorsLaVerne D. Boeck, Hang Chio, Tom E. Eaton, Otis W. Godfrey, Jr., Karl H. Michel, Walter M. Nakatsukasa, Raymond C. Yao
Life of this patent
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Abstract
Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
Claims31
A compound of the formula ##STR4## wherein R is H or a group selected from ##STR5## R.sup.2 is ##STR6## R.sup.1, R.sup.3, R.sup.5 and R.sup.6 are hydrogen or methyl;
- R.sup.4 is methyl or ethyl;
- and
- provided that R, R.sup.1, R.sup.3, R.sup.4 R.sup.5 and R.sup.6 must be present in one of the following combinations:
- ______________________________________ R R.sup.1 R.sup.3 R.sup.4 R.sup.5 R.sup.6 ______________________________________ (a) Me H Et Me Me (b) Me H Et Me Me (c) Me H Et Me Me (a) Me Me Et Me Me (a) Me H Me Me Me (a) H H Et Me Me (d) Me H Et Me Me (a) Me H Et H Me (a) Me H Et Me H H Me H Et Me Me H Me Me Et Me Me H Me H Me Me Me H H H Et Me Me H Me H Et H Me H Me H Et Me H ______________________________________
- an acid addition salt of a compound wherein R is other than hydrogen.
Fermentation product A83543, comprising A83543A, A83543B, A83543C, A83543D, A83543E, A83543F, A83543G, A83543H and A83543J, which is produced by culturing a Saccharopolyspora spinosa strain selected from NRRL 18395, NRRL 18537, NRRL 18538 or NRRL 18539, or an A83543-producing mutant thereof, under submerged aerobic conditions in a suitable culture medium until a recoverable amount of A83543 is produced.
A method of claim wherein the compound is selected from, Formula 1 where R is (a), R.sup.1 is methyl, R.sup.3 is hydrogen, R.sup.4 is ethyl, R.sup.5 is methyl and R.sup.6 is methyl;
- R is (b) , R.sup.1 is methyl, R.sup.3 is hydrogen, R.sup.4 is ethyl, R.sup.5 is methyl and R.sup.6 is methyl;
- R is (c) , R.sup.1 is methyl, R.sup.3 is hydrogen, R.sup.4 is ethyl, R.sup.5 is methyl and R.sup.6 is methyl;
- R is (a), R.sup.1 is methyl, R.sup.3 is methyl, R.sup.4 is ethyl, R.sup.5 is methyl and R.sup.6 is methyl;
- R is (a) , R.sup.1 is methyl, R.sup.3 is hydrogen, R.sup.4 is methyl, R.sup.5 is methyl and R.sup.6 is methyl;
- R is (a) , R.sup.1 is hydrogen, R.sup.3 is hydrogen, R.sup.4 is ethyl, R.sup.5 is methyl and R.sup.6 is methyl;
- R is (d), R.sup. 1 is methyl, R.sup.3 is hydrogen, R.sup.4 is ethyl, R.sup.5 is methyl and R.sup.6 is methyl;
- R is (a) , R.sup.1 is methyl, R.sup.3 is H, R.sup.4 is ethyl, R.sup.5 is hydrogen and R.sup.6 is methyl;
- or R is (a), R.sup.1 is methyl, R.sup.3 is hydrogen, R.sup.4 is ethyl, R.sup.5 is methyl and R.sup.6 is hydrogen or a phytologically acceptable salt thereof.
Dependencies are inferred from the claim text.