Radiopharmaceutical product having in particular a cerebral tropism comprising a nitruro complex of a transition metal and method for preparing said product
AssigneeCIS Bio International
InventorsRoberto Pasqualini, Emmanuel Bellande, Ve/ ronique Comazzi, Jacques Laine/
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Abstract
The invention concerns a radiopharmaceutical product having in particular a cerebral tropism comprising a nitruro complex of a transition metal and the method for preparing said product. This complex satisfies the formula (M.tbd.N)L.sup.1 L.sup.2 (I) in which M is a transition metal, such as Tc99m, Re 186 or Re188, and L.sup.1 and L.sup.2, which may be identical or different, satisfy the formula ##STR1## in which R.sup.1 and R.sup.2 may be alkyl radicals, V and W may be O, S or Se, n=0 or 1, l=0 or 1, m=0 or 1, and X represents N--C, C, or As.
Claims14
A radiopharmaceutical product comprising a complex of a transition metal satisfying the formula:
- (M.tbd.N)L.sup.1 L.sup.2 (I)
- in which M is a radioactive transition metal and in which L.sup.1 and L.sup.2, which may be identical or different, satisfy the formula:
- ##STR47## in which R.sup.1 and R.sup.2, which may be identical or different, represent a linear or branched alkyl radical with 1 to 10 carbon atoms, optionally substituted by at least one group selected from the group consisting of --O--R.sup.3, --OOCR.sup.3, --COOR.sup.3, --CONR.sup.4 R.sup.5 and --NR.sup.4 R.sup.5 in which R.sup.3 is a linear or branched alkyl radical with 1 to 5 carbon atoms, and R.sup.4 and R.sup.5, which may be identical or different, are hydrogen atoms or linear or branched alkyl radicals with 1 to 5 carbon atoms, or in which R.sup.1 and R.sup.2 together form a bivalent bridging hydrocarbon optionally containing one or several heteroatoms, optionally substituted by at least one group selected from the group consisting of --O--R.sup.3, --OOCR.sup.3, --COOR.sup.3, --CONR.sup.4 R.sup.5 and NR.sup.4 R.sup.5 and --NR.sup.4 R.sup.5 in which R.sup.3, R.sup.4, R.sup.5 are as defined above,
- V and W, which may be identical or different, represent O, S or Se,
- X represents C, N--C, P or As, and
- l, m and n, which may be identical or different, are equal to 0 or 1,
- m and n being equal to 0 when X represents C, and m being equal to 1 when X represent N--C, P or As, provided,
- 1) when X represents --N--C--, R.sup.1 or R.sup.2 is an alkyl radical substituted by at least one group which is a --COOR.sup.3 or a --CONR.sup.4 R.sup.5 group, or R.sup.1 and R.sup.2 together form a --COOR.sup.3 or a --CONR.sup.4 R.sup.5 substituted bivalent bridging hydrocarbon optionally containing one or several heteroatoms, and
- 2) when X represents P, with V and W representing O, R.sup.1 and R.sup.2 is a --COOR.sup.3 or a --CONR.sup.4 R.sup.5 substituted alkyl radical or R.sup.1 and R.sup.2 together form a --COOR.sup.3 or a --CONR.sup.4 R.sup.5 substituted bivalent bridging hydrocarbon optionally containing one or several heteroatoms.
Radiopharmaceutical product, wherein it is selected from nitruro-bis (dimethyl)dithiophosphinato) .sup.99m Tc (V), nitruro-bis (diethyl dithiophosphinato) .sup.99m Tc (V), nitruro(dimethyldithiophosphinato, diethyldithiophosphinato) TC.sup.99m (V), nitruro-bis (N-(N,N dimethylethylamino), N-methyl dithiocarbamato) .sup.99m Tc (V), nitruro-bis (N-(N,N diethylethylamino), N-methyl dithiocarbamato) .sup.99m Tc (V), nitruro-bis(N-methylenemethylcarboxylate, N-methyl dithiocarbamato ).sup.99m Tc (V), nitruro-bis (N-methylene ethyl carboxylate, N-methyl dithiocarbamato) .sup.99m Tc (V), nitruro-bis (N-methylene methyl carboxylate, N-ethyl dithiocarbamato) .sup.99m Tc (V), nitruro-bis(N-methylene methyl carboxylate, N-propyl dithiocarbamato) .sup.99m Tc (V), nitruro-bis (N-methylene ethyl carboxylate, N-n-propyl dithiocarbamato) .sup.99m Tc (V), nitruro-bis (3-(methyl carboxylate)piperidino dithiocarbamato) .sup.99m Tc (V), nitruro-bis[bis N-(methylene methyl carboxylate]dithiocarbamato).sup.99m Tc (V), and nitruro-bis (N-ethylene-2-(methyl carboxylate ), N-methyl dithiocarbamato) .sup.99m Tc (V).
Dependencies are inferred from the claim text.