Sulfonic acid derivative and its pharmaceutical application

Sulfonic acid represented by formula I:

• ##STR151## wherein, R.sub.1 is
• (i) --COOR.sub.2 (wherein, R.sub.2 is (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) an alkyl having 1 to 14 carbon atoms) or the group:
• (ii) ##STR152## wherein R.sub.3 represents an alkyl having 1 to 4 carbon atoms);
• A is
• (i) --(CH.sub.2)n-- (wherein, n represents an integer of 0 to 3),
• (ii) --CH.dbd.CH--, or the group:
• (iii) ##STR153## wherein R.sub.4 and R.sub.5 represent (1) hydrogen or (2) an alkyl having 1 to 4 carbon atoms, and R.sub.4 and R.sub.5 may be identical or different);
• and, B is represented with either formula II or formula III:
• ##STR154## wherein R.sub.6 represents
• (i) hydrogen, or
• (ii) --OR.sub.9 (wherein, R.sub.9 represents (1) hydrogen, (2) an alkyl having 1 to 4 carbon atoms, (3) an acyl group having 2 to 5 carbon atoms, or (4) an aroyl group having 7 to 11 carbon atoms),
• Y is --(CH.sub.2)m-- (where, m represents 0 or 1),
• W is ##STR155## R.sub.7 is (i) hydrogen, or
• (ii) an alkyl having 1 to 4 carbon atoms,
• R.sub.8 is
• (i) an alkyl having 1 to 14 carbon atoms, or
• (ii) --Z--R.sub.11 (wherein, Z is a valence bond or a straight or branched alkylene represented by C.sub.t H.sub.2t (where, t is an integer of 1 to 5) and R.sub.11 represents an aryl group or aryl group having 6 to 16 carbon atoms substituted by 1 to 4 groups selected from the group consisting of alkyl, methoxy, chlorine, bromine, fluorine, iodine, trifluoromethyl, nitro, cyano, phenyl and phenoxy)).