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US 5,496,838 AGranted
Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment
AssigneeUniversity of Florida Research Foundation, Inc.
InventorRaymond J. Bergeron
Life of this patent
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Abstract
A method for treating a human or non-human animal afflicted with malignant cells sensitive to parabactin or a pharmaceutically acceptable salt or complex thereof comprising administering to the animal an amount of parabactin effective to inhibit the proliferation of the malignant cells.
Claims8
The method for affecting the activity of ribonucleotide reductase in converting ribonucleotides to deoxyribonucleotides in human and non-human animals comprising administering to said animal in need thereof a ribonucleotide reductase activity affecting amount of a compound of the formula:
- ##STR6## wherein:
- is ##STR7## R is H or OH, x is 3 or 4,
- y is 3 or 4, and
- a is 1, 2 or 3, or a pharmaceutically acceptable salt or complex thereof.
1 more element
Dependencies are inferred from the claim text.