Heterocyclic compounds having angiotensin II antagonistic activity and use thereof

A compound represented by the formula, ##STR46## wherein the ring A is selected from the class consisting of ##STR47## R.sup.1 may be bonded through a hetero atom and stands for an optionally substituted lower (C.sub.1-6) alkyl;

• R.sup.2 stands for a group represented by the formula --CO--D", wherein D" stands for hydroxyl group, amino, N-lower (C.sub.1-4) alkylamino, N,N-di-lower (C.sub.1-4) alkylamino or a lower (C.sub.1-4) alkoxy whose alkyl moiety is optionally substituted with hydroxyl group, amino, halogen, a lower (C.sub.2-6) alkanoyloxy, lower (C.sub.3-7) cycloalkanoyloxy, 1-lower (C.sub.1-6) alkoxycarbonyloxy, lower (C.sub.3-7) cycloalkoxycarbonyloxy or a lower (C.sub.1-4) alkoxy;
• R.sup.3 stands for groups represented by the formula, ##STR48## wherein i stands for --O-- or --S--;
• j stands for >=O, >=S or >S(O).sub.m ;
• and m is of the same meaning as defined above, which are optionally protected with optionally substituted lower (C.sub.1-4) alkyl or an acyl group.

A compound represented by the formula:

• ##STR49## wherein the ring A stands for a pyrazole or pyridine ring optionally having, besides R.sup.1 and R.sup.2, a further substituent selected from the group consisting of halogen, nitro, cyano, an optionally substituted amino group and a group represented by the formula --U--R.sup.6, wherein U is selected from the group consisting of a bond, --O--, --S-- and --CO--, and wherein R.sup.6 is selected from the group consisting of hydrogen, an optionally substituted lower alkyl group and an optionally substituted phenyl group;
• R.sup.1 stands for an optionally substituted hydrocarbon residue selected from the group consisting of
• (i) an alkyl, alkenyl, alkynyl or cycloalkyl group which may be substituted with hydroxy, optionally substituted amino, halogen, lower (C1-4) alkoxy or lower (C1-4) alkylthio and
• (ii) an aryl or aralkyl group which may be substituted with halogen, nitro, optionally substituted amino, lower (C1-4) alkoxy, lower (C1-4) alkylthio or lower (C1-4) alkyl,
• which hydrocarbon residue is optionally bonded through a group of the formula --N(R.sup.9)--, wherein R.sup.9 is selected from the group consisting of hydrogen, lower (C1-4) alkyl, --O-- and --S(O)m--, wherein m is an integer from 0 to 2;
• R.sup.2 stands for an optionally esterified carboxyl group;
• R.sup.3 stands for a group of the formula:
• ##STR50## wherein i is --O-- or --S-- and j is selected from the group consisting of a carbonyl group, a thiocarbonyl group, and an optionally oxidized sulfur atom or a group convertible thereto;
• or a salt thereof.