Inhibition of insulin-induced adiposis
AssigneeThe General Hospital Corporation
InventorsMaria C. Alexander-Bridges, Hui-Fen Zhao
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Abstract
The invention features methods of treating insulin-induced obesity, weight gain, and other conditions associated with hyperinsulinemia.
Claims18
A method of treating obesity caused by hyperinsulinemia, said method comprising the steps of:
- (a) identifying an adult in need of such treatment;
- and
- (b) administering to said adult an amount of rapamycin effective to inhibit insulin-induction of GAPDH, acetyl CoA carboxylase, or GLUT4 gene expression in said adult.
A method of inhibiting weight gain, said method comprising the steps of:
- (a) identifying a patient who is in need of prevention of weight gain resulting from hyperinsulinemia;
- and
- (b) administering to said patient an amount of rapamycin effective to reduce said weight gain.
A method of treating complications of hyperinsulinemia, said method comprising the steps of:
- (a) identifying a patient in need of such treatment;
- and
- (b) administering to said patient an amount of rapamycin effective to inhibit insulin-induction of GAPDH, acetyl CoA carboxylase, or GLUT4 gene expression in said patient.
A method of inhibiting an insulin-stimulated increase in fat content in a cell, said method comprising contacting said cell with an amount of rapamycin effective to inhibit induction of GAPDH, acetyl CoA carboxylase, or GLUT4 gene expression in said cell.
Dependencies are inferred from the claim text.