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US 5,496,825 AGranted
Aconitine compounds and analgesic/anti-inflammatory agent containing the same
AssigneeSanwa Shoyaku Kabushiki Kaisha
InventorsMitsuo Murayama, Takao Mori
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Abstract
Novel aconitine compounds of the formula ##STR1## wherein the symbols are as defined in the description, as well as analgesic/anti-inflammatory agent containing them or salts thereof as active ingredient.
Claims2
An aconitine compound of the formula (I) or a salt thereof:
- ##STR5## wherein R.sub.1 and R.sub.7 are the same and represent methyl or aliphatic or aromatic acyl;
- R.sub.2 is (i) hydrogen,
- (ii) an acyclic or cyclic, saturated or unsaturated alkyl having 1-8 carbon atoms,
- (iii) an oxygen- or nitrogen-containing 5- or 6-membered heterocyclic group,
- (iv) acyl derived from an acyclo- or cyclo-aliphatic, aromatic or aromatic-aliphatic carboxylic acid, or
- (v) aralkyl;
- R.sub.3, R.sub.4 and R.sub.6 are hydrogen;
- and
- R.sub.5 is hydroxyl;
- provided that if R.sub.1 is benzoyl, anisoyl, acetyl, trimethylgalloyl, p-nitrobenzoyl or o-methoxybenzoyl, then R.sub.2 is methyl.
7 more elements
Dependencies are inferred from the claim text.