Use of L-carnitine and alkanoyl L-carnitines in the storage of blood for transfusions and stabilizing solutions containing them
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorArduini Arduino
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Abstract
Solutions which contain L-carnitine and alkanoyl L-carnitine are useful for stabilizing blood for transfusions.
Claims8
A method for stabilizing blood for transfusion, comprising mixing blood with a solution, said solution comprising L-carnitine, alkanoyl L-carnitine, or a pharmaceutically acceptable salt thereof, wherein said pharmaceutically acceptable salt is selected from the group consisting of chloride, bromide, orotate, aspartic acid, acid citrate, acid phosphate, fumarate, acid fumarate, maleate, acid maleate, acid oxalate, acid sulfate, glucoses phosphate, tartrate, and acid tartrate, and wherein said solution comprises 0.5-10.0 mM/L of said L-carnitine, said alkanoyl L-carnitine, or said pharmaceutically acceptable salt thereof.
A transfusion bag which comprises:
- (a) a sample of whole blood;
- (b) a preservative-anticoagulant solution;
- and
- (c) 4-6 mM/L of L-carnitine, alkanoyl L-carnitine or a pharmaceutically acceptable salt thereof, wherein said pharmaceutically acceptable salt is selected from the group consisting of chloride, bromide, orotate, aspartic acid, acid citrate, acid phosphate, fumarate, acid fumarate, maleate, acid maleate, acid oxalate, acid sulfate, glucoses phosphate, tartrate, and acid tartrate.
Dependencies are inferred from the claim text.