Method of modifying bone resorption with .DELTA.9(11)-dehydro-8-isoestrone
AssigneeAmerican Home Products Corporation
InventorsFrederick O. Gemmill, Jr., Chester E. Orzech, Steven J. Adelman
Life of this patent
Estimating the term…
Abstract
This invention relates to 8.alpha.-3-hydroxyestra-1,3,5(10),9(11)tetraen-17-one (.DELTA.9(11)-dehydro-8-isoestrone) (VI), ##STR1## to the process for its preparation, to pharmaceutical compositions containing said 8.alpha.-3-hydroxyestra-1,3,5(10),9(11)tetraen-17-one (.DELTA.9(11)-dehydro-8-isoestrone) (VI) and to the use of said 8.alpha.-3-hydroxyestra-1,3,5(10),9(11)tetraen-17-one (.DELTA.9(11)-dehydro-8-isoestrone) (VI) for modifying the balance between bone production and bone resorption, and as an antioxidant in a host animal, including man.
Claims1
A method of reducing the ratio of the rate of bone resorption to bone formation in a patient in need thereof comprising administering to said patient an effective amount of the compound (VI) ##STR17##
Dependencies are inferred from the claim text.