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US 5,496,810 AGranted
Pyrimidine deoxyribonucleoside potentiation of combination therapy based on 5-fluorouracil and interferon
AssigneeMontefiore Medical Center
InventorEdward L. Schwartz
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Abstract
The applicants have discovered a method of treating malignancies which comprises administering effective amounts of 5-fluorouracil, interferon-.alpha. and a compound formula (I): ##STR1## wherein R is selected is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkene of 2 to 5 carbon atoms and alkynyl of 2 to 5 carbon atoms; R.sub.1 is 2'-deoxyribofuranosyl.
Claims10
A method of treating a neoplasm which is sensitive to the combination of 5-fluorouracil, interferon-.alpha. and a compound of formula (I):
- ##STR4## wherein R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkene of 2 to 5 carbon atoms and alkynyl of 2 to 5 carbon atoms;
- R.sub.1 is 2'-deoxyribofuranosyl, said method comprising administering to a host an amount of said combination which is effective to treat a neoplasm which is sensitive to the combination.
Dependencies are inferred from the claim text.