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US 5,496,581 AGranted
Polymeric coating
AssigneeBiocompatibles Limited
InventorsYiannakis P. Yianni, Martin C. Wiles
Life of this patent
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Abstract
A process for coating a surface comprising applying a solution containing a polymer obtained by polymerizing a phospholipid of the following formula (I): ##STR1##
Claims24
A process for coating a surface comprising applying to the surface a solution of a polymer, in an organic solvent and removing the solvent, wherein the polymer is obtained by polymerizing a phospholipid of formula (I):
- ##STR7## wherein at least one of B.sup.1 and B.sup.2 is a group of the formula (II):
- --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II)
- wherein p is 0 or 1, X.sup.1 is an aliphatic or cycloaliphatic group, Y.sup.1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X.sup.1 and Y.sup.1 in each B.sup.1 and/or B.sup.2 being 8 to 26, and the other of B.sup.1 and B.sup.2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms;
- m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms;
- wherein said polymer contains repeating units of the following formula (III) ##STR8## wherein one of Z.sup.1 and Z.sup.2 is Y.sup.1 as defined above, and one of Z.sup.3 and Z.sup.4 are Y.sup.1 as defined above, and
- wherein the other one of Z.sup.1 and Z.sup.2 and the other one of Z.sup.3 and Z.sup.4 are the formula --X.sup.1 --(CO).sub.p --G, wherein X.sup.1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I).
3 more elements
A process for coating a surface comprising the steps of
- (a) treating said surface with a reactive alkyl silane or plasma polymerizing said surface in the presence of an alkane or alkylsilane,
- (b) after step (a) coating said surface with a solution of a polymer in a solvent selected from the group comprising lower alkanols, halogenated alkanes and mixtures thereof containing from 0.5 to 35 mg/ml of said polymer, by immersion in a coating bath, spraying, or spin coating and
- (c) removing said solvent,
- wherein said polymer is a phospholipid of formula (I) ##STR11## wherein at least one of B.sup.1 and B.sup.2 is a group of the formula (II):
- --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II)
- wherein p is 0 or 1, X.sup.1 is an aliphatic or cycloaliphatic group, Y.sup.1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X.sup.1 and Y.sup.1 in each B.sup.1 and/or B.sup.2 being 8 to 26, and the other B.sup.1 and B.sup.2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms;
- m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms.
4 more elements
A process for coating a surface comprising applying to said surface a solution of a polymer, in an organic solvent and then removing the solvent, wherein the polymer is obtained by polymerizing a phospholipid of formula (I):
- ##STR12## wherein at least one of B.sup.1 and B.sup.2 is a group of the formula (II):
- --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II)
- wherein p is 0 or 1, X.sup.1 is an aliphatic or cycloaliphatic group, Y.sup.1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X.sup.1 and Y.sup.1 in each B.sup.1 and/or B.sup.2 being 8 to 26, and the other of B.sup.1 and B.sup.2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms;
- m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms;
- wherein said polymer contains repeating units of the following formula (III):
- ##STR13## wherein one of Z.sup.1 and Z.sup.2 is Y.sup.1, and one of Z.sup.3 and Z.sup.4 are Y.sup.1,
- wherein the other one of Z.sup.1 and Z.sup.2 and the other one of Z.sup.3 and Z.sup.4 are the formula --X.sup.1 --(CO).sub.p --G, wherein X.sup.1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I),
- wherein said solution comprises from 0.5 to 35 mg/ml of said polymer,
- wherein said process forms a coating having a thickness of from 3 to 1000 nm by application of said solution,
- wherein in said phospholipid of formula (I), B.sup.1 and B.sup.2 each represent
- --CO--(CH.sub.2).sub.8 --C.tbd.C--C.tbd.C--Y.sup.1
- wherein the groups Y.sup.1 are the same or different.
9 more elements
A process for coating a surface comprising:
- pre-treating said surface by plasma polymerization,
- covering said surface with a coating comprising a polymer in a solution in an organic solvent, wherein said polymer is obtained by polymerizing a phospholipid of formula (I):
- ##STR14## wherein at least one of B.sup.1 and B.sup.2 is a group of the formula (II):
- --(CO).sub.p --X.sup.1 --C.tbd.C--C.tbd.C--Y.sup.1 (II)
- wherein p is 0 or 1, X.sup.1 is an aliphatic or cycloaliphatic group, Y.sup.1 is H or a monovalent aliphatic or cycloaliphatic group, the total number of carbon atoms in X.sup.1 and Y.sup.1 in each B.sup.1 and/or B.sup.2 being 8 to 26, and the other of B.sup.1 and B.sup.2 is either (a) the same or a different group of the formula (II) or (b) is an aliphatic or cycloaliphatic group containing at least 8 carbon atoms;
- m is 2, 3 or 4 and each R independently represents an alkyl group containing 1 to 4 carbon atoms;
- wherein said polymer contains repeating units of the following formula (III):
- ##STR15## wherein one of Z.sup.1 and Z.sup.2 are Y.sup.1 as defined above, and one of Z.sup.3 and Z.sup.4 are Y.sup.1 as defined above, and
- wherein the other one of Z.sup.1 and Z.sup.2 and the other one of Z.sup.3 and Z.sup.4 are the formula --X.sup.1 --(CO).sub.p --G, wherein X.sup.1 and p are as defined above, and G is a corresponding remaining portion of the phospholipid of formula (I),
- and then removing said organic solvent.
7 more elements
Dependencies are inferred from the claim text.