Purified mite allergen
AssigneesFumakilla Limited, Hiroshima University
InventorsSatoru Oka, Kazuhisa Ono, Seiko Shigeta, Takeshi Wada
Life of this patent
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Abstract
New purified mite allergens useful as pharmaceutical and diagnostic compositions for the treatment and diagnosis of mite allergic diseases are provided. Both allergens are contained in fecal extracts of mites in culture. The high molecular weight allergen has a weight average molecular weight of 70,000 to 80,000 as determined by sedimentation equilibrium. This is a glycoprotein containing more than about 70% sugar, and possesses allergen activity. The low molecular weight antigen has a molecular weight of 1,500 to 5,000 as determined by Sephadex G25 gel filtration. This is a glycoprotein containing more than about 40% sugar, and also possesses allergen activity.
Claims13
A purified and isolated mite allergen, said allergen possessing the following physicochemical and biological properties:
- 1/ being isolated and purified from fecal extracts of mites in cultures;
- 2/ being a glycoprotein containing more than 70% sugar;
- 3/ having a weight-average molecular weight of 70,000 to 80,000 as determined by sedimentation equilibrium;
- 4/ possessing allergen activity;
- and
- 5/ being unstainable by Coomassie blue.
Dependencies are inferred from the claim text.