Methods and compositions for the treatment of niddm
AssigneeBattelle Development Corporation
InventorsBary W. Wilson, James A. Campbell, Lyle B. Sasser, Patricio Hortal
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Abstract
A variety of hypoglycemic agents and compositions for use in the maintenance of maturity onset non-insulin dependent diabetes mellitus (NIDDM) are disclosed. The present invention also discloses methods for reducing the blood glucose level in a patient, as well as methods for reducing symptomatic conditions associated with diabetes in a patient.
Claims36
A hypoglycemic composition, comprising:
- a polar solvent extract of the leaves, seed pods, roots or bark of the plant Hexachlymus edulis, in combination with a physiologically acceptable carrier or diluent.
A hypoglycemic composition, comprising:
- an ethanol extract, or an aqueous ethanol extract, of the leaves, seed pods, roots or bark of the plant Hexachlymus edulis.
A process for preparing a hypoglycemic agent, comprising:
- macerating the leaves, seed pods, roots or bark of the plant Hexachlymus edulis with a polar solvent.
A process for preparing a hypoglycemic agent, comprising:
- (a) macerating the leaves, seed pods, roots or bark of the plant Hexachlymus edulis with a polar solvent to yield a solution and solid plant debris;
- and
- (b) separating said solution from said solid plant debris, thereby yielding an extract suitable as a hypoglycemic agent.
A method for reducing the blood glucose level in a patient, comprising:
- administering to the patient an amount of a composition effective to reduce the patient's blood glucose level, said composition comprising a polar solvent extract of the leaves, seed pods, roots or bark of the plant Hexachlymus edulis, in combination with a physiologically acceptable carrier or diluent.
A method for reducing polydipsia, polyuria or polyphagia associated with diabetes in a patient, comprising:
- administering to the patient an amount of a composition effective to reduce polydipsia, polyuria or polyphagia in the patient, said composition comprising a polar solvent extract of the leaves, seed pods, roots or bark of the Hexachlymus edulis, in combination with a physiologically acceptable carrier or diluent.
A process for preparing a hypoglycemic agent, comprising:
- (a) preparing a callus from explants of seedlings or plant cuttings of the plant Hexachlymus edulis;
- (b) culturing one or more cells from the callus;
- and
- (c) separating a fraction containing hypoglycemic activity from the culture medium, thereby yielding a fraction suitable as a hypoglycemic agent.
A process for preparing a hypoglycemic agent, comprising:
- (a) infecting cuttings from seedlings of the plant Hexachlymus edulis with a plant pathogen capable of cell transformation;
- (b) culturing one or more infected seedling cells;
- and
- (c) separating a fraction containing hypoglycemic activity from the cultured cells, thereby yielding a fraction suitable as a hypoglycemic agent.
Dependencies are inferred from the claim text.