Osteogenic devices
AssigneeStryker Corporation
InventorsThangavel Kuberasampath, David C. Rueger
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Abstract
Disclosed are osteogenic devices comprising a matrix containing substantially pure mammalian osteogenic protein and methods of inducing endochondral bone growth in mammals. A partial amino acid sequence, amino acid composition, solubility properties, and various other data characterizing osteogenic protein are also disclosed, as well as a nucleic acid sequences encoding a consensus osteogenic protein.
Claims7
An osteogenic device for implantation in a mammal, the device comprising:
- a porous biocompatible matrix;
- and
- substantially pure osteogenic protein disposed in said matrix and comprising a pair of polypeptide chains disulfide bonded to produce a dimeric species having a conformation such that said pair of polypeptide chains is capable of inducing endochondral bone formation in a mammal when disposed within said porous matrix and implanted in a mammal.
A method for accelerating allograft repair in a mammal, the methodcomprising the step of implanting at a locus in need of replacement bone an osteogenic device comprising:
- a porous biocompatible matrix defining a scaffold sufficient to permit the anchoring, proliferation and differentiation of progenitor cells;
- and
- substantially pure osteogenic protein disposed in said matrix and comprising pair of polypeptide chains disulfide bonded to produce a dimeric species having a conformation such that said pair of polypeptide chains is capable of inducing endochondral bone formation in a mammal when disposed within said porous biocompatible matrix and implanted in a mammal.
Dependencies are inferred from the claim text.