Rhenium complexes
AssigneeAustralian Nuclear Science and Technology Organisation
InventorsTimothy W. Jackson, Masaharu Kojima, Richard M. Lambrecht
Life of this patent
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Abstract
Rhenium complexes of formula (I), radiolabelled complexes thereof or pharmaceutically acceptable salts thereof: ##STR1## wherein R is straight or branched chain C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.1-10 alkynyl optionally substituted by cycloalkyl or aryl; C.sub.1-10 cycloalkyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or aryl; or aryl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or cycloalkyl for use in liver cancer therapy and metastasis of cancer.
Claims21
A product comprising a rhenium complex of formula (I):
- ##STR5## wherein the rhenium atom is radioactive, or a pharmaceutically acceptable salt
- wherein R is straight or branched chain C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.1-10 alkynyl optionally substituted by C.sub.5-6 cycloalkyl or phenyl;
- C.sub.5-6 cycloalkyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or phenyl;
- or phenyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or C.sub.5-6 cycloalkyl;
- and
- a lipid soluble oil selected from the group consisting of iodized poppyseed oil.
A product comprising a rhenium complex of formula (I):
- ##STR6## wherein the rhenium atom is radioactive, or a pharmaceutically acceptable salt thereof;
- wherein R is straight or branched chain C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.1-10 alkynyl optionally substituted by C.sub.5-6 cycloalkyl or phenyl;
- C.sub.5-6 cycloalkyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or phenyl;
- or phenyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or C.sub.5-6 cycloalkyl;
- and
- LIPIODOL (iodized poppyseed oil, 38% w/w iodine).
A method of enhancing the efficacy of iodized poppy seed oil in the treatment of liver cancer in a subject which comprises administering to said subject a formulation containing a rhenium complex of formula (I):
- ##STR7## wherein the rhenium atom is radioactive, or a pharmaceutically acceptable salt thereof;
- wherein R is straight or branched chain C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.1-10 alkynyl optionally substituted by C.sub.5-6 cycloalkyl or phenyl;
- C.sub.5-6 cycloalkyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or phenyl;
- or phenyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or C.sub.5-6 cycloalkyl;
- and
- iodized poppyseed oil.
A method of treatment or prophylaxis of liver cancer and metastasis of cancer is a subject comprising administering to the subject a formulation containing a rhenium complex of formula (I):
- ##STR8## wherein the rhenium atom is radioactive, or a pharmaceutically acceptable salt thereof;
- wherein R is straight or branched chain C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.1-10 alkynyl optionally substituted by C.sub.5-6 cycloalkyl or phenyl;
- C.sub.5-6 cycloalkyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or phenyl;
- or phenyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or C.sub.5-6 cycloalkyl;
- and
- wherein the radioactive rhenium complex of formula (I) is administered in combination with iodized poppyseed oil.
Dependencies are inferred from the claim text.