Two dimensional separation system
AssigneeThe University of North Carolina at Chapel Hill
InventorsJames W. Jorgenson, Anthony V. Lemmo
Life of this patent
Estimating the term…
Loading patent…
AssigneeThe University of North Carolina at Chapel Hill
InventorsJames W. Jorgenson, Anthony V. Lemmo
Estimating the term…
A combination liquid chromatography and capillary electrophoresis separation system is disclosed. The system comprises a flow gating interface having an effluent channel and a gating channel formed therein. The gating channel transversely intersects the effluent channel at an intersection portion so that the channels are in fluid communication with one another. The intersection portion divides the effluent channel into an upstream portion and a downstream portion, and divides the gating channel into an upstream portion and a downstream portion. A liquid chromatography column is connected to the effluent channel upstream portion and an electrophoresis capillary is connected to the effluent channel downstream portion. A flush solution inlet line is connected to said gating channel upstream portion, and a flush solution outlet line is connected to the gating channel downstream portion. A valve regulates the flow of flush solution from the flush solution inlet line to the gating channel upstream portion. The intersection portion is configured so that the rate of flow of effluent from the effluent channel upstream portion to the effluent channel downstream portion decreases as the rate of flow of flush solution in the gating channel increases.
A flow gating interface having an effluent channel and a gating channel formed therein, said gating channel transversely intersecting said effluent channel at an intersection portion so that said channels are in fluid communication with one another, with said intersection portion dividing said effluent channel into an upstream portion and a downstream portion, and with said intersection portion dividing said gating channel into an upstream portion and a downstream portion, wherein said gating channel has a larger cross-sectional area than said effluent channel, and wherein said flow gating interface further comprises,
A flow gating interface system, comprising:
A method of gating fluid flow, comprising:
Dependencies are inferred from the claim text.