Non-alkaline purification of aminophosphonic acids
AssigneeCytogen Corporation
InventorsBenjamin A. Belinka, Jr., Daniel J. Coughlin
Life of this patent
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Abstract
A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux, cooled and then filtered. Product purities approaching 100% are thus obtained.
Claims29
A process for the non-alkaline purification of an aminophosphonic acid compound comprising:
- a) combining a previously prepared aminophosphonic acid compound of a given purity and water having a neutral or acidic but not alkaline pH to form a slurry;
- b) heating said slurry to reflux;
- c) maintaining said slurry at reflux for a period of time in the range of about 1 to about 96 hours;
- and
- d) filtering said slurry of step c at or below reflux temperature to obtain an aminophosphonic acid compound of greater purity than said previously prepared aminophosphonic acid compound.
A process for the non-alkaline purification of EDTMP comprising:
- a) combining a previously prepared EDTMP of a given purity and water having a neutral or acidic but not alkaline pH to form a slurry;
- b) heating said slurry to reflux;
- c) maintaining said slurry at reflux for a period of time in the range of about 1 to about 96 hours;
- and
- d) filtering said slurry of step c at or below reflux temperature to obtain EDTMP of greater purity than said previously prepared EDTMP.
A process for the non-alkaline purification of DOTMP comprising:
- a) combining a previously prepared DOTMP of a given purity and water having a neutral or acidic but not alkaline pH to form a slurry;
- b) heating said slurry to reflux;
- c) maintaining said slurry at reflux for a period of time in the range of about 1 to about 96 hours;
- and
- d) filtering said slurry of step c at or below reflux temperature to obtain DOTMP of greater purity than said previously prepared DOTMP.
A process for the non-alkaline purification of an aminophosphonic acid compound comprising:
- a) combining a previously prepared aminophosphonic acid compound of a given purity and water having an acidic, not alkaline, pH to form a slurry;
- b) heating said slurry to reflux;
- c) maintaining said slurry at reflux for a period of time in the range of about 1 to about 96 hours;
- and
- d)filtering said slurry of step c at or below reflux temperature to obtain an aminophosphonic acid compound of greater purity than said previously prepared aminophosphonic acid compound.
A process for the non-alkaline purification of an aminophosphonic acid compound comprising:
- a) combining a previously prepared aminophosphonic acid compound of a given purity and water having a neutral or acidic but not alkaline pH to form a slurry;
- b) heating said slurry to reflux;
- and
- c) filtering said slurry of step (b) at or below reflux temperature to obtain an aminophosphonic acid compound of greater purity than said previously prepared aminophosphonic acid compound.
Dependencies are inferred from the claim text.