9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines

A compound of the formula:

• ##STR28## wherein:
• Y is selected from (CH.sub.2).sub.n X, n=0-5, X is halogen selected from bromine, chlorine, fluorine and iodine;
• R is selected from hydrogen;
• straight or branched (C.sub.1 -C.sub.8)alkyl group selected from methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, heptyl and octyl;
• .alpha.-mercapto(C.sub.1 -C.sub.4)alkyl group selected from mercaptomethyl, .alpha.-mercaptoethyl, .alpha.-mercapto-1-methylethyl, .alpha.-mercaptopropyl and .alpha.-mercaptobutyl;
• .alpha.-hydroxy(C.sub.1 -C.sub.4)alkyl group selected from hydroxymethyl, .alpha.-hydroxyethyl, .alpha.-hydroxy-1-methylethyl, .alpha.-hydroxypropyl and .alpha.-hydroxybutyl;
• carboxyl(C.sub.1 -C.sub.8)alkyl group;
• (C.sub.6 -C.sub.10)aryl group selected from phenyl, .alpha.-naphthyl and .beta.-naphthyl;
• substituted(C.sub.6 -C.sub.10)aryl group wherein the substitution is selected from hydroxy, halogen, (C.sub.1 -C.sub.4)alkoxy, trihalo(C.sub.1 -C.sub.3) alkyl, nitro, amino, cyano, (C.sub.1 -C.sub.4)alkoxycarbonyl, (C.sub.1 -C.sub.3)alkylamino and carboxy;
• (C.sub.7 -C.sub.9)aralkyl group selected from benzyl, 1-phenylethyl, 2-phenylethyl and phenylpropyl;
• substituted(C.sub.7 -C.sub.9)aralkyl group wherein the substitution selected from halo, (C.sub.1 -C.sub.4)alkyl, nitro, hydroxy, amino, mono- or di-substituted (C.sub.1 -C.sub.4)alkylamino, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylsulfonyl, cyano and carboxy;
• R.sup.1 is selected from hydrogen and (C.sub.1 -C.sub.6)alkyl selected from methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl and hexyl;
• when R does not equal R.sup.1 the stereochemistry of the asymmetric carbon (i.e. the carbon bearing the Y substituent) maybe be either the racemate (DL) or the individual enantiomers (L or D);
• or a pharmacologically acceptable organic or inorganic salt or metal complex thereof.