Piperidines and piperazines
AssigneeMerck Patent GmbH
InventorsManfred Baumgarth, Inge Lues, Klaus-Otto Minck, Norbert Beier
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Abstract
Piperidine and piperazine derivatives of formula I ##STR1## wherein R.sup.1 and R.sup.2 are H or A, R.sup.3, R.sup.4 and R.sup.5 are each independently H, Hal, OH, OA, OAc, NO.sub.2, NH.sub.2, NHAc, NHSO.sub.2 A or CN, or R.sup.3 and R.sup.4 together are --O--(CH.sub.2).sub.m --O--, n is 0, 1 or 2 X is O or CH.sub.2, if n=0 or 2, or CH.sub.2, NH, NA or NAc, if n=1, Y is CH or N, m is 1 or 2, Hal is F, Cl, Br or I, A is C.sub.1-6 -alkyl, Ac is C.sub.1-8 -alkanoyl C.sub.1-10 -aralkanoyl or C.sub.7-11 -aroyl, and their physiologically acceptable salts show antiarrhythmic effects.
Claims15
A piperidine or piperazine compound of formula I ##STR6## wherein R.sup.1 and R.sup.2 are H or A,
- R.sup.3, R.sup.4 and R.sup.5 are each independently H, Hal, OH, OA, OAc, NO.sub.2, NH.sub.2, NHAc, NHSO.sub.2 A or CN, or
- R.sup.3 and R.sup.4 together are --O--(CH.sub.2).sub.m --O--,
- n is 0, 1 or 2
- X is O or CH.sub.2, if n=0 or 2, or CH.sub.2, NH, NA or NAc, if n=1,
- Y is CH or N,
- m is 1 or 2,
- Hal is F, Cl, Br or I,
- A is C.sub.1-6 -alkyl, and
- Ac is C.sub.1-8 -alkanoyl C.sub.1-10 -aralkanoyl or C.sub.7-11 -aroyl,
- or an enantiomer or a physiologically acceptable salt thereof.
Dependencies are inferred from the claim text.