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US 5,495,010 AGranted
Acid stable purine dideoxynucleosides
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsVictor E. Marquez, John S. Driscoll, Christopher K-H. Tseng, James A. Kelley, David G. Johns, Hiroaki Mitsuya
Life of this patent
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Abstract
Purine nucleosides active against human immunodeficiency virus which are substituted at the 2'-position by a strong electronegative group such as fluorine are stable in an acid environment and thus can be used for oral administration.
Claims4
The compound 2',3'-dideoxy-2'-beta-fluoroadenosine.
The compound 2',3'-dideoxy-2'-beta-fluoroinosine.
The compound 2',3'-dideoxy-2'-beta-fluoroguanosine.
Dependencies are inferred from the claim text.