Delivery formulation for probucol
AssigneeVyrex Corporation
InventorsRobert A. Sanchez, Sheldon S. Hendler
Life of this patent
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Abstract
A lipophilic pharmaceutical formulation including a digestible vegetable oil and a phenolic antioxidant such as probucol is disclosed for oral administration. The probucol will typically be present in an amount of between 5 and about 15% by weight and the digestible vegetable oil will be present in an amount of between about 80 and 95% by weight. A small quantity of ethanol may be added to the formulation to increase the solubility of probucol. The formulations will be orally administered for treatment of hypercholesterolemic patients and others suffering from certain ailments.
Claims18
A lipophilic pharmaceutical formulation for oral administration consisting essentially of a digestible medium chain triglyceride and probucol, said probucol having a concentration greater than about 5% by weight, and said probucol being completely dissolved in said digestible medium chain triglyceride.
A method for increasing probucol absorption by an organism, said method comprising orally administering to the organism a solution consisting essentially of greater than about 5% by weight probucol dissolved in a digestible medium chain triglyceride.
Dependencies are inferred from the claim text.