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US 5,494,930 AGranted
Caribenolide I
OwnerYuzuru Shimizu, Craig R. Fairchildinventors
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Abstract
Compound (1), isolated from a marine dinoflagellate, is a novel macrolide which has potent in vitro cytotoxicity against human colon carcinoma cell line HCT116 (IC.sub.50 =1.6 nM) and a multiple drug resistant subline. In addition, this compound has good in vivo antitumor activity against a P388 mouse leukemia (150% T/C).
Claims4
A new antitumor compound, in substantially pure form, having the structure:
- ##STR2##
Dependencies are inferred from the claim text.