Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
AssigneeHoechst-Roussel Pharmaceutical Inc.
InventorsGerard J. O'Malley, Mark G. Palermo
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Abstract
This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
Claims31
A compound of the formula ##STR230## wherein X is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkoxymethyleneoxy, aryl(C.sub.1 -C.sub.6)alkoxy, halo, hydroxy, (C.sub.1 -C.sub.6)alkanoylamino, aminocarbonyloxy, (C.sub.1 -C.sub.10)alkylaminocarbonyloxy, di(C.sub.1 -C.sub.10)alkylaminocarbonyloxy, aryl(C.sub.1 -C.sub.10)alkylaminocarbonyloxy, (C.sub.1 -C.sub.6)alkoxycarbonyloxy, tetrahydroisoquinolylcarbonyloxy or aryl(C.sub.1 -C.sub.6)alkylcarbonyloxy;
- R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl, aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, aryloxycarbonyl, aryl(C.sub.1 -C.sub.6)alkoxycarbonyl, aminocarbonyl, (C.sub.1 -C.sub.6)alkylaminocarbonyl, or di(C.sub.1 -C.sub.6)alkylaminocarbonyl;
- m is an integer from 2 to 7;
- n is an integer from 0 to 3;
- and
- pharmaceutically acceptable acid addition salts thereof and optical and geometric isomers or racemic mixtures thereof.
A compound of the formula ##STR231## wherein X is hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkoxymethyleneoxy, aryl(C.sub.1 -C.sub.6)alkoxy, halo, hydroxy, (C.sub.1 -C.sub.6)alkanoylamino, aminocarbonyloxy, (C.sub.1 -C.sub.10)alkylaminocarbonyloxy, di(C.sub.1 -C.sub.10)alkylaminocarbonyloxy, aryl(C.sub.1 --C.sub.10)alkylaminocarbonyloxy, (C.sub.1 -C.sub.6)alkoxycarbonyloxy, tetrahydroisoquinolylcarbonyloxy or aryl(C.sub.1 -C.sub.6)alkylcarbonyloxy;
- R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl, aryl(C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxycarbonyl, aryloxycarbonyl, aryl(C.sub.1 -C.sub.6)alkoxycarbonyl, aminocarbonyl, (C.sub.1 -C.sub.6)alkylaminocarbonyl, or di(C.sub.1 -C.sub.6)alkylaminocarbonyl;
- m is an integer from 2 to 7;
- n is an integer from 0 to 3;
- and
- pharmaceutically acceptable acid addition salts thereof and optical and geometric isomers or racemic mixtures thereof.
Dependencies are inferred from the claim text.