26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27-dimethylene-24-EPI-1.alpha.,25-dihydroxyvitamin D.sub.2 and methods for preparing same
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Naoshi Nakagawa
Life of this patent
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Abstract
Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced onto the 25-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and its 24-epimer. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.
Claims8
A method of treating metabolic bone disease where it is desired to maintain or increase bone mass comprising administering to a patient with said disease a compound having the formula
- where R.sup.1 and R.sup.2 are hydrogen or methyl with the proviso that when R.sup.1 is hydrogen R.sup.2 cannot be hydrogen and when R.sup.1 is methyl R.sup.2 cannot be methyl.
Dependencies are inferred from the claim text.