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US 5,494,900 AGranted
UDPG as a rescue agent in cancer therapy after the administration of antipyrimidine or related anti-tumor agents with or without BAU
AssigneeBoehringer Mannheim Italia S.p.A.
InventorRobert L. Stolfi
Life of this patent
Estimating the term…
Abstract
A method of rescuing healthy cells of a cancer patient being treated with antipyrimidine antitumor compounds, or related compounds. Rescue is accomplished by administering UDPG after administering the antipyrimidine antitumor compound preferably with BAU administration.
Claims12
A method for treating a tumor sensitive to treatment with the combination recited below in a patient comprising:
- administering to said patient an anti-tumor effective amount of 5-fluorouracil, said amount of 5-fluorouracil being an amount which is toxic to said patient;
- administering an effective amount of UDPG which is effective to provide in said patient a uridine plasma level which provides rescue from said amount of 5-fluorouracil, said amount of UDPG not causing side effects which would be caused if uridine alone were used to provide said uridine plasma level;
- and
- administering an anti-catabolic-effective amount of BAU, said amount of BAU being from 5 to 200 times said amount of 5-fluorouracil.
1 more element
A method for treating a tumor sensitive to treatment with the combination recited below in a patient comprising:
- administering to said patient an anti-tumor effective amount of antipyrimidine agent selected from the group consisting of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil, 1-[2-[(2-dimethyl-n-octyl-silyl-5-ethyl)thiol] ethylcarbamoyl-5-fluoro-uracil, Tegafur, and Carmofur, said anti-tumor effective amount being toxic to said patient;
- administering an amount of UDPG which is effective to provide in said patient a uridine plasma level which provides rescue from said anti-tumor effective amount, said amount of UDPG not causing side effects which would be caused if uridine alone were used to provide said uridine plasma level;
- and
- administering an anti-catabolic-effective amount of BAU, said amount of BAU being from 5 to 200 times said anti-tumor effective amount.
1 more element
Dependencies are inferred from the claim text.