Stylostatin 2
AssigneeArizona Board of Regents, a body corporate acting on behalf of Arizona State University
InventorsGeorge R. Pettit, Jayaram K. Srirangam
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Abstract
The cytostatic cycloheptapeptide stylostatin 2 was isolated respectively, from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing high-field (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration was established by chiral gas chromatographic analytical technique. The cyclic heptapeptide backbone was found to include a .beta.-turn, type VIa, incorporating a cis peptide bond, at -Ser-Pro.
Claims2
A substantially pure composition of matter denominated stylostatin 2 and having the structure:
- ##STR18##
A composition of matter comprising a pharmaceutically acceptable carrier and, as its essential active ingredient, a small but effective amount of stylostatin 2.
Dependencies are inferred from the claim text.