Streptomyces braegensis strain and its cultivation in a process for producing C.sub.9 -desoxo-FK-520
AssigneePfizer Inc.
InventorsWalter P. Cullen, Mark A. Guadliana, Liang H. Huang, Keiji Kaneda, Nakao Kojima, Gloria Kostek, Satoshi Nishiyama, Yuji Yamauchi, Yasuhiro Kojima
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Abstract
A compound of the formula ##STR1## is a novel immunosuppressant agent prepared by fermenting Steptomyces braeaensis subsp. pulcherrimus, ATCC 55150, or another compound of the formula I producing strain and extracting the compound of the formula I from the fermentation medium. The compound is useful in treating transplant rejection and autoimmune diseases.
Claims7
A process for preparing a compound of the formula ##STR4## comprising fermenting an organism having all of the identifying characteristics of Streptomyces braegensis subsp. pulcherrimus Huang subsp. nov., ATCC 55150, under aerobic conditions in an aqueous medium containing a carbon source and a nitrogen source and recovering said compound of formula I by extracting the fermentation broth with an organic solvent at a pH of about 4.0 to about 8.0.
A biologically pure culture having all of the identifying characteristics of Streptomyces braegensis subsp. pulcherrimus Huang subsp. nov., ATCC 55150, and any mutant thereof capable of producing the compound of the formula ##STR5##
Dependencies are inferred from the claim text.