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AssigneeVirogenetics Corporation
InventorsEnzo Paoletti, Marion E. Perkus, Jill Taylor, James Tartaglia, Elizabeth K. Norton, Michel Riviere, Charles de Taisne, Keith J. Limbach, Gerard P. Johnson, Steven E. Pincus, William I. Cox, Jean-Christophe F. Audonnet, Russell R. Gettig
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What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
A recombinant vaccinia virus wherein regions C7L.-K1L, J2R, B13R+B14R, A26L, A56R and I4L have been deleted therefrom, and further comprising exogenous coding DNA from a non-vaccinia source in a nonessential region of the vaccinia genome.
A recombinant vaccinia virus wherein the open reading frames for the thymidine kinase gene, the hemorrhagic region, the A type inclusion body region, the hemagglutinin gene, the host range gene region, and, the large subunit, ribonucleotide reductase have been deleted therefrom, and further comprising exogenous coding DNA from a non-vaccinia source in a nonessential region of the vaccinia genome.
An immunological composition for inducing an immunological response in a host inoculated with the composition, said composition comprising a carrier and a recombinant virus as claimed in any one of claims 2, 33, 44, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20.
Dependencies are inferred from the claim text.