Monoclonal antibodies against glycated low density lipoprotein
AssigneeExocell, Inc.
InventorMargo P. Cohen
Life of this patent
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Abstract
An antibody specifically immunoreactive with glycated LDL and methods for using the antibody are provided. The antibody can be used for quantitating amounts of glycated LDL in a sample, for monitoring glycemic control in diabetic patients, for diagnosing disease, for monitoring and diagnosing atherosclerotic cardiovascular disease, and for inhibiting accumulation of LDL cholesterol by cells in tissues subject to atherosclerotic disease.
Claims18
A monoclonal antibody which specifically immunoreacts with an epitope comprising N-deoxyfructosyllysine, which epitope is present in glycated LDL (low density lipoprotein), but said epitope is not present in unglycated LDL or in other glycated or unglycated plasma proteins, wherein said epitope is present in apolipoprotein B of glycated LDL.
Dependencies are inferred from the claim text.