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US 5,494,681 AGranted
Tastemasked pharmaceutical materials
AssigneeKV Pharmaceutical Company
InventorsRobert C. Cuca, Ronald S. Harland, Thomas C. Riley, Jr., Yury Lagoviyer, R. Saul Levinson
Life of this patent
Estimating the term…
Abstract
A substantially tasteless pharmaceutical delivery system, which comprises a) an active material; and b) a spatially oriented matrix comprising (i) a wax core material having a melting point within the range of about 50.degree. C. and about 200.degree. C.; and (ii) a regional hydrophobic polymer material and method for making the same.
Claims14
A substantially tasteless pharmaceutical delivery system, which comprises a molten blend of:
- a) an active material;
- and
- b) a spatially oriented matrix comprising:
- (i) a major amount of about 10% to about 95% by weight of the matrix of a wax core material having a melting point within the range of about 50.degree. C. and about 200.degree. C.;
- and
- (ii) a minor amount of about 1% to about 50% by weight of the matrix of a hydrophobic polymer material selected from the group consisting of natural polymers and synthetic polymers,
- wherein the total amount of the matrix is equal to 100%.
4 more elements
A substantially tasteless pharmaceutical delivery system which comprises:
- a) an effective amount of an active material selected from the group consisting of analgesics, anti-inflammatories, antihistamines, antitussives, expectorants, decongestants, narcotics, antibiotics, bronchodilators, cardiovasculars, central nervous system drugs, minerals, vitamins, metal salts, and mixtures thereof;
- and
- b) a spatially oriented matrix comprising:
- (i) from about 10% to about 95% of a wax core material having a melting point within the range of about 50.degree. C. and about 200.degree. C.;
- and
- (ii) from about 1% to about 50% of a hydrophobic polymer material;
- and remaining amount up to 100% of an additional excipient.
4 more elements
Dependencies are inferred from the claim text.