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US 5,494,680 AGranted
Transdermal delivery device
AssigneeMinnesota Mining and Manufacturing Company
InventorTimothy A. Peterson
Life of this patent
Estimating the term…
Abstract
A transdermal drug delivery device involving a backing bearing at least one adhesive layer of an acrylate copolymer and a therapeutically effective amount of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole. The device optionally further involves (i) a second adhesive layer of an acrylate copolymer and optionally a therapeutically effective amount of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole, and (ii) a membrane intermediate the first and second adhesive layers.
Claims27
A transdermal delivery device comprising:
- (A) a backing;
- (B) an adhesive layer adhered to one surface of the backing and comprising a homogeneous mixture of
- (1) a copolymer comprising
- (a) about 80 to 98 percent by weight of an alkyl acrylate or methacrylate containing 4 to 10 carbon atoms in the alkyl group, based on the weight of all monomers in the copolymer;
- and
- (b) about 2 to 20 percent by weight of a monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing 1 to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl substituted acrylamide, diacetone acrylamide and N-vinyl-2-pyrrolidone, based on the weight of all monomers in the copolymer;
- and
- (2) about 5 to about 35 percent by weight based on the total weight of the adhesive layer of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole.
5 more elements
A transdermal delivery device comprising:
- (A) a backing;
- (B) an adhesive layer adhered to one surface of the backing and comprising a homogeneous mixture of
- (1) a copolymer comprising
- (a) about 60 to 80 percent by weight of an alkyl acrylate or methacrylate containing 4 to 10 carbon atoms in the alkyl group, based on the weight of all monomers in the copolymer;
- (b) about 4 to 9 percent by weight of a monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing 1 to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl substituted acrylamide, diacetone acrylamide and N-vinyl-2-pyrrolidone, based on the weight of all monomers in the copolymer;
- and
- (c) about 15 to 35 percent by weight of vinyl acetate, based on the weight of all monomers in the copolymer;
- and
- (2) about 5 to about 35 percent by weight based on the total weight of the adhesive layer of (S)-3-methyl-5-(1-methyl-2pyrrolidinyl)isoxazole.
6 more elements
A transdermal delivery device comprising:
- (A) a backing;
- (B) a first adhesive layer adhered to one surface of the backing and comprising an adhesive selected from the group consisting of:
- (1) a copolymer comprising
- (a) about 80 to 98 percent by weight of an alkyl acrylate or methacrylate containing 4 to 10 carbon atoms in the alkyl group, based on the weight of all monomers in the copolymer;
- and
- (b) about 2 to 20 percent by weight of a monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing 1 to carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl substituted acrylamide, diacetone acrylamide and N-vinyl-2-pyrrolidone, based on the weight of all monomers in the copolymer;
- and
- (2) a copolymer comprising
- (a) about 60 to 80 percent by weight of an alkyl acrylate or methacrylate containing 4 to 10 carbon atoms in the alkyl group, based on the weight of all monomers in the copolymer;
- (b) about 4 to 9 percent by weight of a monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing 1 to carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl substituted acrylamide, diacetone acrylamide and N-vinyl-2-pyrrolidone, based on the weight of all monomers in the copolymer;
- and
- (c) about 15 to 35 percent by weight of vinyl acetate, based on the weight of all monomers in the copolymer;
- (C) a second adhesive layer comprising an adhesive selected from the group consisting of:
- (1) a copolymer comprising
- (a) about 80 to 98 percent by weight of an alkyl acrylate or methacrylate containing 4 to 10 carbon atoms in the alkyl group, based on the weight of all monomers in the copolymer;
- and
- (b) about 2 to 20 percent by weight of a monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing 1 to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl substituted acrylamide, diacetone acrylamide and N-vinyl-2-pyrrolidone, based on the weight of all monomers in the copolymer;
- and
- (2) a copolymer comprising
- (a) about 60 to 80 percent by weight of an alkyl acrylate or methacrylate containing 4 to 10 carbon atoms in the alkyl group, based on the weight of all monomers in the copolymer;
- (b) about 4 to 9 percent by weight of a monomer selected from the group consisting of acrylic acid, methacrylic acid, an alkyl acrylate or methacrylate containing 1 to 3 carbon atoms in the alkyl group, acrylamide, methacrylamide, a lower alkyl substituted acrylamide, diacetone acrylamide and N-vinyl-2-pyrrolidone, based on the weight of all monomers in the copolymer;
- and
- (c) about 15 to 35 percent by weight of vinyl acetate, based on the weight of all monomers in the copolymer;
- and
- (D) a membrane between the first and second adhesive layers, the membrane being permeable to (S)-3-methyl-5-( 1-methyl-2-pyrrolidinyl)isoxazole,
- wherein at least one of said first and second adhesive layers further comprises about 5 to about 35 percent by weight based on the total weight of the adhesive layer of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole in admixture therewith.
23 more elements
Dependencies are inferred from the claim text.