Molecules for iontophoretic delivery
AssigneeBecton, Dickinson and Company
InventorsBurton H. Sage, Jr., Randal A. Hoke
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Abstract
The invention discloses peptides and proteins for iontophoretic delivery. Specifically disclosed are methods for iontophoretic delivery of assemblages of amino acids which comprises modifying said assemblages of amino acids to an isoelectric point less than about 4.0 or greater than about 7.3 with an electrostatic charge of plus or minus 1 and patches with assemblages of amino acids with isoelectric points less than about 4.0 or greater than about 7.3 with an electrostatic charge of plus or minus 1.
Claims18
A method for preparing proteins or peptides for iontophoretic delivery comprising:
- modifying said proteins or peptides by chemical modification to an isoelectric point less than about 4.0 or greater than about 7.3 with an electrostatic charge of at least plus or minus 1 over the pH range of about 4.0 to about 7.3.
A patch for iontophoretic delivery which comprises proteins and peptides having an isoelectric point of less than about 4.0 or greater than about 7.3 with at least an electrostatic charge of plus or minus 1 over the pH range, of human skin, of about 4.0 to about 7.3.
A method for preparing proteins or peptides for iontophoretic delivery comprising:
- modifying said proteins or peptides by amino acid substitution to an isoelectric point less than about 4.0 or greater than about 7.3 with an electrostatic charge of at least plus or minus 1 over the pH range of about 4.0 to about 7.3.
A method for preparing proteins or peptides for iontophoretic delivery comprising:
- modifying said proteins or peptides by amino acid addition or deletion to an isoelectric point less than about 4.0 or greater than about 7.3 with an electrostatic charge of at least plus or minus 1 over the pH range of about 4.0 to about 7.3.
Dependencies are inferred from the claim text.