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US 5,494,677 AGranted
Tissue-specific implantable therapeutic agent delivery system
OwnerVincent C. Giampapainventor
Life of this patent
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Abstract
A system for tissue-specific delivery of therapeutic agents includes an implantable element. biodegradable in situ within human tissue; a vasoinductive agent integrated into a surface of the element; and having the therapeutic agents incorporated into the implantable element. Upon implantation of the implantable element into tissue, the vasoinductive agent stimulates capillary growth, facilitating delivery of the therapeutic agents to the selected tissue.
Claims7
A biodegradable implant for delivery of pharmakinetic agents, comprising:
- (a) a therapeutically effective amount of a vasoinductive agent;
- (b) in physical communication with said vasoinductive agent, a biodegradable element having affixed thereto at least one pharmakinetic agent, said biodegradable element comprising a series of radially concentric shells having respectively different pharmakinetic agents, or respectively different combinations of said pharmakinetic agents, disposed upon each of said respective, radially concentric shells such that the outermost shell and its associated agents will be delivered earliest while the innermost shell and its corresponding agents will be delivered last to a human tissue of interest,
- whereby, upon implantation of said biodegradable implant into said human tissue, said vasoinductive agent will stimulate capillary growth to thereby facilitate delivery of said pharmakinetic agents as a function of the rate of in vivo dissolution of said biodegradable element within said human tissue.
Dependencies are inferred from the claim text.