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US 5,494,673 AGranted
Phosphazene polyelectrolytes as immunoadjuvants
AssigneeVirus Research Institute
InventorsAlexander K. Andrianov, Sharon A. Jenkins, Lendon G. Payne, Bryan E. Roberts
Life of this patent
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Abstract
An immunoadjuvant soluble polyphosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.
Claims18
A method for producing an immune response in an animal comprising:
- producing an immune response in an animal by administering to the animal an antigen and a polyphosphazene polyelectrolyte adjuvant in an amount effective to elicit an immune response in the animal against said antigen, said polyphosphazene being at least partially soluble in water.
Dependencies are inferred from the claim text.