Stimulator for bone formation
AssigneeOno Pharmaceutical Co., Ltd.
InventorsUeno Kohji, Teruaki Katayama, Tsumoru Miyamoto
Life of this patent
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Abstract
A stimulator for bone formation containing human interleukin 4 or an analogue thereof as an active ingredient. This stimulator is useful for the prevention and treatment of, for example, osteoporosis, osteogenesis imperfecta, injured bone and abnormality of dental and the improvement of metabolic abnormality of bone.
Claims6
A method of stimulating the formation of bone in a human patient, comprising administering to a human patient bone stimulating effective amounts of substances selected from the group consisting of (1) recovered and purified human interleukin 4, (2) a substance wherein amino acids of the peptide structure of human interleukin 4 are subjected to sugar addition, (3) recombinant human interleukin 4, and (4) an analogue of human interleukin 4 wherein amino acids of the polypeptide structure of human interleukin 4 are replaced with amino acids such that the analogue exhibits bone stimulating activity.
A method of stimulating the formation of osteoblasts, comprising administering to a human patient bone stimulating effective amounts of substances selected from the group consisting of (1) recovered and purified human interleukin 4, (2) a substance wherein amino acids of the peptide structure of human interleukin 4 are subjected to sugar addition, (3) recombinant human interleukin-4, and (4) an analogue of human interleukin 4 wherein amino acids of the polypeptide structure of human interleukin 4 are replaced with amino acids such that the analogue exhibits bone stimulating activity.
A method of stimulating the formation of bone in a human patient, comprising administering to a human patient bone stimulating effective amounts of substances selected from the group consisting of
- (1) recovered and purified natural human interleukin 4,
- (2) a substance having the polypeptide structure of natural human interleukin 4 wherein amino acids of the polypeptide structure are subjected to sugar addition;
- and
- (3) recombinant human interleukin 4.
A method of stimulating the formation of osteoblasts, comprising administering to a human patient bone stimulating effective amounts of substances selected from the group consisting of
- (1) recovered and purified natural human interleukin 4,
- (2) a substance having the polypeptide structure of natural human interleukin 4 wherein amino acids of the polypeptide structure are subjected to sugar addition;
- and
- (3) recombinant human interleukin 4.
Dependencies are inferred from the claim text.