Radiolabelled compound formulations
AssigneeAmersham International plc
InventorsRoger M. Price, Christopher C. May, Elizabeth M. Buckley, Timothy Stone
Life of this patent
Estimating the term…
Abstract
Additives are proposed for compositions comprising radiolabelled organic compounds e.g. 32P-labelled nucleotides. Stabilisers are selected from tryptophan, para-aminobenzoate, indoleacetate and the azole group. Dyes are selected from Sulphorhodamine B, Xylene Cyanol, Azocarmine B and New Coccine. Preferred compositions contain both stabiliser and dye.
Claims11
A composition comprising an organic compound labeled with a .beta.-emitting radionuclide, said radiolabelled organic compound being subject to radiolytic decomposition during storage and shipment, together with a stabilizer selected from the group consisting of tryptophan, indoleacetate and luminol including the free acids and salts and esters thereof, and the group of azoles which are compounds having a five-membered ring with at least two ring nitrogen atoms directly bonded to one another.
A composition comprising a radiolabelled organic compound labelled with a .beta.-emitting radionuclide, a dye, and a stabilizer selected from the group consisting of tryptophan, indoleacetate and luminol, including the free acids and salts and esters thereof, and the group of azoles which are compounds having a five-membered ring with at least two ring nitrogen atoms directly bonded to one another.
A composition comprising a radiolabelled organic compound labelled with a .beta.-emitting radionuclide, a dye, and para-aminobenzoate, which term includes the free acid and salts and esters thereof, as a stabilizer, wherein the organic compound is not a dye.
Dependencies are inferred from the claim text.