Process for the manufacture of p-phenetidine
AssigneeTambour, Ltd.
InventorJacob Kalo
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Abstract
A process for the manufacture of para-phenetidine is described. The process comprises the following steps: (a) diazotizing para-phenetidine and coupling the resulting compound to phenol at a molar ratio of 1.3 to 1 phenol to the diazo compound;(b) ethylating the resulting compound at a temperature in the range of between 130.degree. C. to 200.degree. C., and (c) catalytically hydrogenating the ethylated compound, whereby two moles of para-phenetidine are produced, one of which being recycled as the starting reagent in the first step. The product obtained is of a high purity being substantially free from the undesired isomers.
Claims10
A process for the manufacture of p-phenetidine which comprises the steps of:
- (a) diazotizing p-phenetidine and coupling the resulting compound to phenol at a molar ratio of 1.3-1.0 phenol to diazo;
- (b) ethylating the compound obtained in step (a) at a temperature in the range of between 130.degree. C.-200.degree. C.;
- and
- (c) catalytically hydrogenating the ethylated compound obtained in step (b) whereby 2 moles of p-phenetidine are produced, one of which is recycled as starting reagent in step (a).
Dependencies are inferred from the claim text.