Gel-forming liquid carrier composition
AssigneePharmacia Corporation
InventorsConny Bogentoft, Anders Carlsson
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Abstract
A carrier composition that is a liquid at or below room temperature forms a high viscosity layer or gel at body temperature, which comprises a water-soluble, nonionic cellulose ether having a cloud point not higher than 40.degree. C., a charged surfactant and optional additives in water. The carrier composition can be used for oral or local administration of a pharmacologically active substance to the skin, mucous membrane, the eye or a body cavity.
Claims20
A carrier composition which is a liquid at or below room temperature and forms a high viscosity layer or gel at body temperature, characterized in comprising a water-soluble, nonionic cellulose ether having a cloud point not higher than 40.degree. C., a charged surfactant and optional additives in water wherein said optional additives are selected from the group consisting of flavoring agents, colorants, preservatives, isotonic agents and mixtures thereof, and in that the combined concentration of the water-soluble, nonionic cellulose ether and the surfactant is below 3% by weight, and wherein the remainder of the composition is water and said optional additives.
A pharmaceutical composition which is liquid at and below room temperature and forms a high viscosity layer or gel at body temperature, characterized in comprising a water-soluble, nonionic cellulose ether having a cloud point not higher than 40.degree. C., an amphiphilic drug and optional additives in water, wherein said optional additives are selected from the group consisting of flavoring agents, colorants, preservatives, isotonic agents and mixtures thereof, and wherein the combined concentration of the water-soluble, nonionic cellulose ether and the surfactant is below 3% by weight, and wherein the remainder of the composition is water and said optional additives.
Dependencies are inferred from the claim text.