Bimodal molecular weight hyaluronate formulations and methods for using same
AssigneeAllergan, Inc.
InventorsJames E. Francese, F. Richard Christ
Life of this patent
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Abstract
Compositions and methods useful for protecting human or animal eye cell layers and tissues exposed to trauma, e.g., during surgery, are disclosed. In one embodiment, the method comprises administering a protective amount of an ophthalmically acceptable aqueous composition containing a first alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of at least about 2 million, for example, in the range of about 2 million to about 4 million, and a second alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of about 200,000 to about 800,000, for example, in the range of about 300,000 to 700,000, to eye cell layers and tissues prior to the exposure to the trauma.
Claims10
A method for removing the natural lens from the eye of a human or animal which comprises:
- introducing a protective amount of an ophthalmically acceptable aqueous composition into said eye of said human or animal, said ophthalmically acceptable aqueous composition comprising water, a first sodium hyaluronate fraction having a weight average molecular weight in the range of about 2 million to about 4 million, and a second sodium hyaluronate fraction having a weight average molecular weight in the range of about 400,000 to about 700,000, the weight ratio of said first sodium hyaluronate fraction to said second sodium hyaluronate fraction in said ophthalmically acceptable aqueous composition is in the range of about 0.1 to about 4, said ophthalmically acceptable aqueous composition adhering to at least one portion of the eye in proximity to said natural lens in said eye, said introducing step being more easily conducted relative to a similar introducing step employing a similar ophthalmically acceptable aqueous composition containing none of said first sodium hyaluronate fraction;
- causing said natural lens to break into a plurality of particles, said composition being more effective in protecting said eye of said human or animal during said causing step relative to a similar ophthalmically acceptable aqueous composition containing none of said second sodium hyaluronate fraction;
- removing said plurality of particles;
- and
- removing said ophthalmically acceptable aqueous composition from said eye.
Dependencies are inferred from the claim text.