US 5,492,935 A · Compositions comprising retinal and derivatives thereof for treatment of cosmetic or dermatologic skin disorders

Abstract

Therapeutic as well as preventive measures to improve cosmetic conditions and to alleviate the symptoms of dermatologic disorders with retinal and its derivatives is disclosed. Cosmetic conditions and dermatologic disorders in humans and domestic animals in which retinal and its derivatives may be useful include age spots, wrinkles, warts, eczema, seborrheic keratoses, acne, oily skin, psoriasis, dandruff, xerosis, inflammatory and pruritic skin, disturbed keratinization, skin changes associated with aging and possibly viral infections. Retinal and its derivatives include their stereoisomers, for example, all-trans, 13-cis, 11-cis, 9-cis, 7-cis, 11,13-cis and 9,13-cis vitamin A aldehydes, their hydrate, hemiacetal and acetal forms, and their adduct compounds. Compositions containing retinal or its derivative may be administered systemically such as orally, or topically to the affected areas of the skin.

Claims16

Dependent claims

A method of alleviating warts, comprising administering topically or by intralesion injection to involved areas of the body a retinal compound having the formula:

##STR1## wherein R.sub.1 and R.sub.2 represent alkyl, cycloalkyl, aralkyl, aryl or alkoxy group of saturated or unsaturated, isomeric or non-isomeric form, having 1 to 25 carbon atoms, provided, however, when R.sub.1 and R.sub.2 represent aralkyl or aryl the number of carbon atoms shall be at least 6 and without fused aromatic rings,
R.sub.3 represents O or (OR.sub.4) (OR.sub.5), wherein R.sub.4 and R.sub.5 represent H, alkyl, cycloalkyl, aralkyl or aryl group of saturated or unsaturated, isomeric or non-isomeric form, having 1 to 25 carbon atoms;
provided, however, when R.sub.4 and R.sub.5 represent aralkyl or aryl the number of carbon atoms shall be at least 6 and without fused aromatic rings, and the hydrogen atom attached to the carbon atom in the main chain as well as in R.sub.1, R.sub.2, R.sub.4 and R.sub.5 may be substituted by a halogen atom or a lower alkyl or alkoxy radical having 1 to 9 carbon atoms;
or stereoisomers thereof in a cosmetically acceptable vehicle.

1 more element

A therapeutic composition for cosmetic or dermatologic skin disorders comprising (A) a retinal compound having the formula:

##STR2## wherein R.sub.1 and R.sub.2 represent alkyl, cycloalkyl, aralkyl, aryl or alkoxy group of saturated or unsaturated, isomeric or non-isomeric form, having 1 to 25 carbon atoms, provided, however, when R.sub.1 and R.sub.2 represent aralkyl or aryl the number of carbon atoms shall be at least 6 and without fused aromatic rings,
R.sub.3 represents O or (OR.sub.4) (OR.sub.5), wherein R.sub.4 and R.sub.5 represent H, alkyl, cycloalkyl, aralkyl or aryl group of saturated or unsaturated, isomeric or non-isomeric form, having 1 to 25 carbon atoms;
provided, however, when R.sub.4 and R.sub.5 represent aralkyl or aryl the number of carbon atoms shall be at least 6 and without fused aromatic rings, and the hydrogen atom attached to the carbon atom in the main chain as well as in R.sub.1, R.sub.2, R.sub.4 and R.sub.5 may be substituted by a halogen atom or a lower alkyl or alkoxy radical having 1 to 9 carbon atoms;
or stereoisomers thereof;
and (B) an effective amount of a therapeutic, cosmetic or dermatologic agent in a pharmaceutically acceptable vehicle for systemic administration or for topical application to involved body areas.

2 more elements

A method of improving cosmetic or dermatologic skin disorders comprising administering systemically or topically to involved areas a composition comprising (A) a retinal compound having the formula:

##STR3## wherein R.sub.1 and R.sub.2 represent alkyl, cycloalkyl, aralkyl, aryl or alkoxy group of saturated or unsaturated, isomeric or non-isomeric form, having 1 to 25 carbon atoms, provided, however, when R.sub.1 and R.sub.2 represent aralkyl or aryl the number of carbon atoms shall be at least 6 and without fused aromatic rings,
R.sub.3 represents O or (OR.sub.4) (OR.sub.5), wherein R.sub.4 and R.sub.5 represent H, alkyl, cycloalkyl, aralkyl or aryl group of saturated or unsaturated, isomeric or non-isomeric form, having 1 to 25 carbon atoms;
provided, however, when R.sub.4 and R.sub.5 represent aralkyl or aryl the number of carbon atoms shall be at least 6 and without fused aromatic rings, and the hydrogen atom attached to the carbon atom in the main chain as well as in R.sub.1, R.sub.2, R.sub.4 and R.sub.5 may be substituted by a halogen atom or a lower alkyl or alkoxy radical having 1 to 9 carbon atoms;
or stereoisomers thereof;
and (B) an effective amount of a therapeutic, cosmetic or dermatologic agent in a pharmaceutically acceptable vehicle for systemic administration or for topical application to involved body areas.

2 more elements

Dependencies are inferred from the claim text.

Compositions comprising retinal and derivatives thereof for treatment of cosmetic or dermatologic skin disorders

Life of this patent

Compositions comprising retinal and derivatives thereof for treatment of cosmetic or dermatologic skin disorders

Life of this patent

Abstract

Claims16