Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
AssigneeEli Lilly and Company
InventorsGeorge J. Cullinan, Jai P. Singh, Dan L. Wood
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Abstract
Methods of inhibiting vascular smooth muscle cell proliferation and vascular restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sub.1 and R.sub.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sub.2 is ##STR3## R.sub.4 is hydrogen or --OR.sub.1, and pharmaceutically acceptable salts and solvates thereof.
Claims6
A method of inhibiting vascular smooth muscle cell proliferation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR8## ##STR9## wherein Ar is optionally substituted phenyl;
- ##STR10## R.sub.4 is hydrogen or --OR.sub.1, and pharmaceutically acceptable salts and solvates thereof.
A method of inhibiting vascular restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR11## ##STR12## wherein Ar is optionally substituted phenyl;
- R.sub.2 is ##STR13## R.sub.4 is hydrogen or --OR.sub.1, and pharmaceutically acceptable salts and solvates thereof.
Dependencies are inferred from the claim text.